PAD4 Antibody / Protein-arginine deiminase type-4 / PADI4-多抗-深圳欣博盛生物科技有限公司

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PAD4 Antibody / Protein-arginine deiminase type-4 / PADI4

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：R31153

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PAD4 Antibody / Protein-arginine deiminase type-4 / PADI4

产品描述:

Peptidylarginine Deiminase, Type IV is a human protein which in humans is encoded by the PADI4 gene. Peptidylarginine deiminases make up a family of posttranslational modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ion(Nakashima et al., 1999). Suzuki et al.(2003) found from sequence data that the gene maps to 1p36. Cuthbert et al.(2004) described a process, deimination, that converts histone arginine to citrulline and antagonizes arginine methylation. They showed that the protein specifically deiminated arg2, arg8, arg17, and arg26 in the H3 tail. Deimination by PAD4 prevented arginine methylation by CARM1. Dimethylation of arginines prevented deimination by PAD4, although monomethylation still allowed deimination to take place. In vivo targeting experiments on an endogenous promoter demonstrated that the protein could repress hormone receptor-mediated gene induction. It was recruited to the pS2 promoter following hormone induction when the gene was transcriptionally downregulated, consistent with a repressive role.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

同种型:

Rabbit IgG

免疫原:

An amino acid sequence from the middle region of human PAD4 (ASPRSCYKLFQEQQNEGHGEA) was used as the immunogen for this PAD4 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

After reconstitution, the PAD4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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