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折扣/货期| 货号：CDX-P0590-M005 | 规格：5 mg | 目录价：￥798 |
| 货号：CDX-P0590-M025 | 规格：25 mg | 目录价：￥3290 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Palbociclib
别名:
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one; PD 0332991; PD-332991; PD991; PF 00080665
产品描述:
Palbociclib is a potent and selective inhibitor of CDK4 (IC50=11nM) and CDK6 (IC50=16nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases. It exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures and displays in vivo efficacy against various advanced stage human tumor xenografts in mice. It inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models. Induces autophagy and senescence in AGS gastric cancer cells. It is a clinically useful breast cancer agent. In addition cell cycle inhibitors have been shown to boost tumor immunogenicity.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
447.53
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at RT.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
571190-30-2
分子式:
C24H29N7O2
溶解度:
Soluble in DMSO (2mg/ml).
促销活动
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