官网链接
折扣/货期| 货号：CDX-P0590-M005 | 规格：5 mg | 目录价：￥826 |
| 货号：CDX-P0590-M025 | 规格：25 mg | 目录价：￥3416 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Palbociclib
别名:
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one; PD 0332991; PD-332991; PD991; PF 00080665
产品描述:
Palbociclib is a potent and selective inhibitor of CDK4 (IC50=11nM) and CDK6 (IC50=16nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases. It exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures and displays in vivo efficacy against various advanced stage human tumor xenografts in mice. It inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models. Induces autophagy and senescence in AGS gastric cancer cells. It is a clinically useful breast cancer agent. In addition cell cycle inhibitors have been shown to boost tumor immunogenicity.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
447.53
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
571190-30-2
分子式:
C24H29N7O2
您可能感兴趣的产品
GAPDH antibody [GA1R]
货号：GTX82560
O-Carbamyl-D-serine
货号：20324
Benarthin
货号：20323
Ceramidastin, Bacterial ceramidase inhibitor
货号：19378
DDCAD < inhibitor of COMT, cyclic AMP phosphodiesterase and DOPA decarboxylase >
货号：18723
Pyridomycin, Antimycobacterial, Enoyl-ACP Reductase Inhibitor
货号：10080
Probestin, Aminopeptidase M Inhibitor, Aminopeptidase N Inhibitor
货号：367
STAT3-IN-12
货号：44651-10 mg
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询