Parsaclisib-抑制剂-深圳欣博盛生物科技有限公司

首页产品中心抑制剂

Parsaclisib

品牌：Cayman

官网链接

说明书

折扣/货期

货号：29784-1 mg	规格：1 mg	目录价：￥1112
货号：29784-10 mg	规格：10 mg	目录价：￥7745
货号：29784-25 mg	规格：25 mg	目录价：￥16589
货号：29784-5 mg	规格：5 mg	目录价：￥4985

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Parsaclisib

别名:

INCB 050465

产品描述:

A PI3Kδ inhibitor (IC50 = 1 nM); selective for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >10,000 nM for all), as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 µM; inhibits primary human B cell proliferation (IC50 = 0.2 nM) and memory T cell cytokine production (IC50s = 0.2-1.5 nM); inhibits the differentiation of naïve isolated human T cells into Th1, Th2, or Th17 T helper cells; inhibits the proliferation of JeKo-1, Mino, Rec-1, and JVM-2 lymphoma cells (IC50s = 50s = 2-8 nM); reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg; reduces proteinuria, lymphadenopathy, and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg; reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögren’s syndrome

保存温度:

-20

运输温度:

-20

预期分子量:

432.879023

产品形式:

A solid

纯度:

≥95%

CAS号:

1426698-88-5