Pemetrexed (sodium salt hydrate)-抑制剂-深圳欣博盛生物科技有限公司

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Pemetrexed (sodium salt hydrate)

品牌：Cayman

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说明书

折扣/货期

货号：14269-10 mg	规格：10 mg	目录价：￥1662
货号：14269-100 mg	规格：100 mg	目录价：￥12033
货号：14269-5 mg	规格：5 mg	目录价：￥911
货号：14269-50 mg	规格：50 mg	目录价：￥6901

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Pemetrexed (sodium salt hydrate)

产品描述:

An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase

保存温度:

-20

运输温度:

-20

预期分子量:

597.5

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

357166-29-1