| 货号:AG-40B-0081-3010 | 规格:3 x 10 ug | 目录价:¥3360 |
| 货号:AG-40B-0081-C010 | 规格:10 ug | 目录价:¥1680 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Periostin [OSF-2] (mouse) (rec.)
别名:
Osteoblast-specific Factor 2; OSF-2; Postn
产品描述:
Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
宿主来源:
CHO cells
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~85kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Rescues sphere formation from periostin KO primary tumor cells at 50ng/ml.
内毒素水平:
<0.1EU/µg purified protein (LAL test; Lonza).
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