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折扣/货期| 货号：19185-1 mg | 规格：1 mg | 目录价：￥536 |
| 货号：19185-10 mg | 规格：10 mg | 目录价：￥3966 |
| 货号：19185-25 mg | 规格：25 mg | 目录价：￥7906 |
| 货号：19185-5 mg | 规格：5 mg | 目录价：￥2117 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PF-3644022
产品描述:
An MK2 inhibitor (IC50 = 5.2 nM); selective for MK2 over MK3, MNK-1, MNK-2, MSK1, MSK2, and RSK1-4 (IC50s = 53, 3,000, 148, >1,000, >1,000, and >1,000 nM, respectively), as well as a panel of 200 other kinases at 1 µM, but also inhibits MK5/PRAK (IC50 = 5 nM); inhibits LPS-induced TNF-α production in U937 cells and isolated human PBMCs and whole blood (IC50s = 0.159, 0.16, and 1.97 µM, respectively); reduces paw swelling in a rat model of streptococcal cell wall-induced arthritis (ED50 = 20 mg/kg); prevents decreases in motor function in a twy/twy mouse model of chronic cervical spinal cord compression at 30 mg/kg; peritumoral administration enhances radiation-induced decreases in tumor volume and increases in survival in a PDX mouse model of HNSCC
保存温度:
-20
运输温度:
-20
预期分子量:
374.5
产品形式:
A solid
纯度:
≥95%
CAS号:
1276121-88-0
分子式:
C21H18N4OS
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