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折扣/货期| 货号：FY12031 | 规格：100 ul | 目录价：￥6488.05 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-Src (Tyr529) Antibody
产品描述:
Phospho-Src (Tyr529) antibody detects Src kinase phosphorylated at tyrosine 529, a regulatory modification that maintains Src in an inactive conformation. Src is a non-receptor tyrosine kinase involved in diverse cellular pathways, including proliferation, adhesion, and cytoskeletal dynamics. Phosphorylation at Tyr529 creates an intramolecular interaction that suppresses kinase activity until signaling cues trigger dephosphorylation and activation.
Research employing Phospho-Src (Tyr529) antibody has shown that deregulation of this phosphorylation site contributes to oncogenesis. Loss of inhibitory phosphorylation at Tyr529 results in constitutively active Src, promoting tumor cell invasion, angiogenesis, and metastasis. Beyond cancer, Src regulation impacts immune signaling, bone metabolism, and neuronal communication, underscoring its broad biological relevance.
Antibodies specific for Src phosphorylated at Tyr529 are used in assays such as western blot, immunoprecipitation, and immunofluorescence. These reagents allow scientists to measure Src activation status and investigate how signaling pathways modulate its phosphorylation. Clone-validated specificity ensures recognition of only the phosphorylated form, avoiding cross-reactivity with total Src protein.
NSJ Bioreagents supplies this Phospho-Src (Tyr529) antibody to support research into cancer signaling, kinase regulation, and cellular communication. Alternate names include proto-oncogene tyrosine-protein kinase Src antibody and pp60c-Src antibody.
Research employing Phospho-Src (Tyr529) antibody has shown that deregulation of this phosphorylation site contributes to oncogenesis. Loss of inhibitory phosphorylation at Tyr529 results in constitutively active Src, promoting tumor cell invasion, angiogenesis, and metastasis. Beyond cancer, Src regulation impacts immune signaling, bone metabolism, and neuronal communication, underscoring its broad biological relevance.
Antibodies specific for Src phosphorylated at Tyr529 are used in assays such as western blot, immunoprecipitation, and immunofluorescence. These reagents allow scientists to measure Src activation status and investigate how signaling pathways modulate its phosphorylation. Clone-validated specificity ensures recognition of only the phosphorylated form, avoiding cross-reactivity with total Src protein.
NSJ Bioreagents supplies this Phospho-Src (Tyr529) antibody to support research into cancer signaling, kinase regulation, and cellular communication. Alternate names include proto-oncogene tyrosine-protein kinase Src antibody and pp60c-Src antibody.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, ICC, IF
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-Src (Y529) was used as the immunogen for the Phospho-Src (Tyr529) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
32S01
纯化方式:
Affinity-chromatography
保存温度:
Store the Phospho-Src (Tyr529) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA
产地:
美国
上一个:TIMM44 Antibody / Translocase of inner mitochondrial membrane 44
下一个:Histone H3 (mono methyl K14) Antibody / HIST1H3A
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