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折扣/货期| 货号：FY12053 | 规格：100 ul | 目录价：￥6488.05 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-Tau (Ser198) Antibody / MAPT
产品描述:
Phospho-Tau (Ser198) antibody detects tau protein (MAPT) phosphorylated at serine 198, a modification associated with cytoskeletal regulation and neurodegeneration. Tau stabilizes microtubules in neurons, but abnormal phosphorylation weakens this interaction and promotes aggregation into neurofibrillary tangles, a hallmark of Alzheimer's disease and related tauopathies.
Research with Phospho-Tau (Ser198) antibody shows that phosphorylation at Ser198 occurs early in tau pathology and may precede other modifications. This residue is phosphorylated by kinases such as GSK-3beta and CDK5, linking it to pathways commonly dysregulated in Alzheimer's disease. Monitoring Ser198 phosphorylation provides insight into the progression of tau-driven neuronal dysfunction.
Antibodies specific for phospho-tau (Ser198) are validated for applications including western blot, immunohistochemistry, and immunofluorescence. These tools allow selective detection of phosphorylated tau, supporting studies of biomarker development and therapeutic strategies.
NSJ Bioreagents supplies this Phospho-Tau (Ser198) antibody for neurodegeneration and signal transduction research.
Research with Phospho-Tau (Ser198) antibody shows that phosphorylation at Ser198 occurs early in tau pathology and may precede other modifications. This residue is phosphorylated by kinases such as GSK-3beta and CDK5, linking it to pathways commonly dysregulated in Alzheimer's disease. Monitoring Ser198 phosphorylation provides insight into the progression of tau-driven neuronal dysfunction.
Antibodies specific for phospho-tau (Ser198) are validated for applications including western blot, immunohistochemistry, and immunofluorescence. These tools allow selective detection of phosphorylated tau, supporting studies of biomarker development and therapeutic strategies.
NSJ Bioreagents supplies this Phospho-Tau (Ser198) antibody for neurodegeneration and signal transduction research.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, IHC, IP
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-Tau (S198) was used as the immunogen for the Phospho-Tau (Ser198) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
31M15
纯化方式:
Affinity-chromatography
保存温度:
Store the Phospho-Tau (Ser198) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA
产地:
美国
上一个:MRPL11 Antibody / Mitochondrial ribosomal protein L11
下一个:ELOVL5 Antibody / Elongation of very long chain fatty acids protein 5
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