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折扣/货期| 货号：37306-100 mg | 规格：100 mg | 目录价：￥1139 |
| 货号：37306-250 mg | 规格：250 mg | 目录价：￥2265 |
| 货号：37306-500 mg | 规格：500 mg | 目录价：￥4234 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PK11000
产品描述:
A stabilizer of mutant p53; covalently binds to Cys182 and Cys277, increases the thermal stability, and inhibits the aggregation of the p53Y220C DNA-binding domain at 1 mM; selectively decreases the viability of mutant p53-expressing SW480 (p53R273H,P309S), NUGC-3 and Huh7 (p53Y220C), and MKN1 (p53V143A) cancer cells over wild-type p53-expressing NUGC-4, HuH-6, and SJSA-1 cancer cells; not selective between H1299 p53-/- and H1299 p53R175H cells; increases expression of the p53 target genes p21 and PUMA and decreases the expression MDM2 in Huh7 and MKN1 cells at 15 µM; increases ROS levels in Huh7 and MKN1 cells
保存温度:
-20
运输温度:
-20
预期分子量:
236.63368
产品形式:
A solid
纯度:
≥95%
CAS号:
38275-34-2
分子式:
C6H5ClN2O4S
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