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折扣/货期| 货号：21896-1 mg | 规格：1 mg | 目录价：￥536 |
| 货号：21896-10 mg | 规格：10 mg | 目录价：￥3296 |
| 货号：21896-25 mg | 规格：25 mg | 目录价：￥7517 |
| 货号：21896-5 mg | 规格：5 mg | 目录价：￥1769 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PKI-166
产品描述:
An inhibitor of EGFR (IC50 = 0.0007 µM for the intracellular kinase domain); selective for the EGFR intracellular kinase domain over the serine/threonine kinases PKC-α and Cdc2/cyclin B (IC50s = >100 and 78 µM, respectively), as well as FLK, c-Met, and Tek (IC50 = >1 µM for all), but does inhibit c-Src, c-Abl, VEGFR2/KDR, FLT1, and c-Kit (IC50s = 0.103, 0.028, 0.327, 0.962, and 2.21 µM, respectively); enhances the cytotoxicity of gemcitabine in L3.6pl cells; reduces tumor growth and metastasis and increases survival in an L3.6pl mouse xenograft model at 100 mg/kg per day with additive effects when administered in combination with gemcitabine; reduces tumor growth and inhibits angiogenesis in an SN12-PM6 human renal cell carcinoma mouse orthotopic model
保存温度:
-20
运输温度:
-20
预期分子量:
330.4
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
187724-61-4
分子式:
C20H18N4O
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