PLpro (SARS Coronavirus) (rec.) (His)-重组病毒蛋白-深圳欣博盛生物科技有限公司

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PLpro (SARS Coronavirus) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-DE0024-C050

规格：50 ug

目录价：￥3332

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PLpro (SARS Coronavirus) (rec.) (His)

别名:

Papain-like Proteinase; SARS Coronavirus Main Proteinase; Non-structural Protein 3; PL2-PRO; Nsp3

产品描述:

The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63 linked polyubiquitin chains (free chains or from cellular substrates). It works in concert together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It strongly antagonizes the innate immune induction of type I interferon by blocking the phosphorylation, dimerization and therefore the nuclear translocation of host IRF3. In addition, it prevents also host NF-kappa-B signaling.

宿主来源:

E. coli

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

~37kDa

产品形式:

liquid