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折扣/货期| 货号：28927-10 mg | 规格：10 mg | 目录价：￥2036.8 |
| 货号：28927-25 mg | 规格：25 mg | 目录价：￥3229.4 |
| 货号：28927-5 mg | 规格：5 mg | 目录价：￥1393.6 |
| 货号：28927-50 mg | 规格：50 mg | 目录价：￥5735.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PLX5622
产品描述:
A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm
保存温度:
-20
运输温度:
-20
预期分子量:
395.405466
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
1303420-67-8
分子式:
C21H19F2N5O
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