官网链接
折扣/货期| 货号：36277-1 mg | 规格：1 mg | 目录价：￥429 |
| 货号：36277-10 mg | 规格：10 mg | 目录价：￥2720 |
| 货号：36277-25 mg | 规格：25 mg | 目录价：￥4154 |
| 货号：36277-5 mg | 规格：5 mg | 目录价：￥1675 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PLX5622 (hemifumarate)
产品描述:
A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm in the chow
保存温度:
-20
运输温度:
-20
预期分子量:
395.405466
产品形式:
A solid
纯度:
≥98%
分子式:
C21H19F2N5O • 1/2C4H4O4
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