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折扣/货期| 货号：AG-CR1-3905-M001 | 规格：1 mg | 目录价：￥1440 |
| 货号：AG-CR1-3905-M005 | 规格：5 mg | 目录价：￥5760 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PMPH
别名:
4-((1H-Pyrazol-1-yl)methyl)-N-hydroxybenzamide
产品描述:
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
217.2
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1392835-64-1
分子式:
C11H11N3O2
溶解度:
Soluble in DMSO, methanol or ethanol.
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