Polycystin 1 Antibody / PKD1-多抗-深圳欣博盛生物科技有限公司

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Polycystin 1 Antibody / PKD1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：R36500-100UG

规格：100 ug

目录价：￥6863.75

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Polycystin 1 Antibody / PKD1

产品描述:

Polycystin 1, also known as PKD1, is a protein encoded by the PKD1 gene and is crucial in the development of Polycystic Kidney Disease (PKD). PKD1 mutations are responsible for the majority of cases of autosomal dominant PKD, a genetic disorder that causes the formation of fluid-filled cysts in the kidneys. Polycystin 1 is a transmembrane protein that plays a vital role in cell-cell and cell-matrix interactions. It is primarily expressed in the kidneys, liver, pancreas, and other tissues, where it helps regulate cell proliferation, differentiation, and apoptosis. Dysfunction of Polycystin 1 disrupts these essential cellular processes, leading to the formation of cysts in the kidneys. Research has shown that Polycystin 1 interacts with other proteins, such as Polycystin 2, to form a protein complex that regulates calcium signaling and cell growth. Mutations in PKD1 disrupt this complex, causing aberrant calcium signaling and uncontrolled cell proliferation, which ultimately results in cyst formation and kidney damage. Studies have also suggested that Polycystin 1 may play a role in the mechanosensory function of kidney epithelial cells, allowing them to respond to changes in fluid flow and pressure within the nephron. Dysregulation of this mechanosensory function due to PKD1 mutations may contribute to the development and progression of PKD.

反应种属:

Human

宿主来源:

Goat

实验应用:

IHC-P, ELISA (peptide)

同种型:

Goat Ig

免疫原:

Amino acids RTPLRAKNKVHP were used as the immunogen for this Polycystin 1 antibody.

克隆性:

Polyclonal (goat origin)