PROTAC EGFR Degrader 9-其他小分子化合物-深圳欣博盛生物科技有限公司

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PROTAC EGFR Degrader 9

品牌：Cayman

官网链接

说明书

折扣/货期

货号：45393-1 mg	规格：1 mg	目录价：￥2613
货号：45393-10 mg	规格：10 mg	目录价：￥10452
货号：45393-5 mg	规格：5 mg	目录价：￥6539.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PROTAC EGFR Degrader 9

别名:

Proteolysis-targeting Chimera EGFR Degrader-9|Proteolysis-targeting Chimera Epidermal Growth Factor Receptor Degrader-9

产品描述:

A PROTAC that drives mutant EGFR degradation; selectively induces degradation of mutant EGFRs over wild-type EGFR (DC50s = 10.2, 36.5, 88.5, 75.4, and >300 nM for EGFRL858R/T790M/C797S, EGFRΔ19/T790M/C797S, EGFRL858R/T790M, EGFRΔ19, and wild-type EGFR, respectively); inhibits the growth of H1975 cells expressing mutant EGFRL858R/T790M/C797S (IC50 = 10.3 nM) and induces cell cycle arrest at the G0/G1 phase and apoptosis in the same cells; reduces tumor size in H1975 xenograft mouse model at 25 and 100 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

899.991209

产品形式:

A solid

有效期:

1460

纯度:

≥95%