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折扣/货期| 货号：45393-1 mg | 规格：1 mg | 目录价：￥2613 |
| 货号：45393-10 mg | 规格：10 mg | 目录价：￥10452 |
| 货号：45393-5 mg | 规格：5 mg | 目录价：￥6539 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PROTAC EGFR Degrader-9
别名:
Proteolysis-targeting Chimera EGFR Degrader-9|Proteolysis-targeting Chimera Epidermal Growth Factor Receptor Degrader-9
产品描述:
A PROTAC that drives mutant EGFR degradation; selectively induces degradation of mutant EGFRs over wild-type EGFR (DC50s = 10.2, 36.5, 88.5, 75.4, and >300 nM for EGFRL858R/T790M/C797S, EGFRΔ19/T790M/C797S, EGFRL858R/T790M, EGFRΔ19, and wild-type EGFR, respectively); inhibits the growth of H1975 cells expressing mutant EGFRL858R/T790M/C797S (IC50 = 10.3 nM) and induces cell cycle arrest at the G0/G1 phase and apoptosis in the same cells; reduces tumor size in H1975 xenograft mouse model at 25 and 100 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
899.991209
产品形式:
A solid
纯度:
≥95%
CAS号:
2992670-33-2
分子式:
C45H48F3N9O6S
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