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折扣/货期| 货号：40967 | 规格：1 mg | 目录价：￥1849 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PROTAC RAF Degrader 1
别名:
Proteolysis-targeting Chimera RAF Degrader 1|SJF-0628
产品描述:
A PROTAC; selectively induces the degradation of B-RAFV600E over wild-type B-RAF in SK-MEL-239 cells at 10 to 1,000 nM; inhibits wild-type B-RAF and a panel of mutant B-RAF isoforms (IC50s = 5.8 and 1.87 nM); reduces the viability of SK-MEL-28, SK-MEL-239, and SK-MEL-246 melanoma cells (EC50s = 215, 37, and 243 nM, respectively); reduces tumor growth and volume in an SK-MEL-246 mouse xenograft model at 50 mg/kg twice per day
保存温度:
-20
运输温度:
-20
预期分子量:
1010.183546
产品形式:
A solid
纯度:
≥98%
CAS号:
2413035-41-1
分子式:
C51H57F2N9O7S2
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