深圳欣博盛生物科技有限公司

PTPRR Antibody / Protein tyrosine phosphatase receptor type R

PTPRR antibody recognizes protein tyrosine phosphatase receptor type R, an enzyme that belongs to the receptor-type protein tyrosine phosphatase family. This phosphatase regulates phosphorylation states within signaling cascades, modulating pathways critical for cell differentiation, adhesion, and neuronal communication. PTPRR is expressed predominantly in the brain, where it interacts with and dephosphorylates mitogen-activated protein kinases (MAPKs). By controlling MAPK activity, PTPRR influences neuronal development and synaptic plasticity, making it an important regulator in the central nervous system.

Studies using PTPRR antibody have associated this protein with neurological disorders. Alterations in PTPRR signaling may contribute to diseases such as Parkinson's disease, Alzheimer's disease, and schizophrenia due to its involvement in regulating MAPK signaling balance. PTPRR has also been implicated in tumorigenesis, as phosphatases can act as either tumor suppressors or facilitators of oncogenic signaling depending on cellular context. Research continues to explore whether PTPRR expression patterns could serve as biomarkers or therapeutic targets.

Antibodies against PTPRR have been validated for applications including western blot, immunohistochemistry, and immunofluorescence. These reagents allow investigators to detect protein distribution in neuronal tissue or evaluate changes in phosphorylation-dependent signaling under experimental conditions. Clone-based versions provide high specificity, ensuring consistent results in both in vitro and in vivo studies.

NSJ Bioreagents provides this PTPRR antibody for research use, supporting investigations into brain development, signaling regulation, and disease mechanisms. Alternate names include protein tyrosine phosphatase receptor type R antibody, PTP-SL antibody, PTPRQ antibody, and PTPR-SL antibody.

Human, Mouse, Rat

Rabbit

WB, IHC

Rabbit IgG

A synthesized peptide derived from human PTPRR was used as the immunogen for the PTPRR antibody.

Recombinant Rabbit Monoclonal

29P99

Affinity-chromatography

Store the PTPRR antibody at -20oC.

Liquid

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

美国