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折扣/货期| 货号：13745-1 mg | 规格：1 mg | 目录价：￥1996.6 |
| 货号：13745-10 mg | 规格：10 mg | 目录价：￥15919.2 |
| 货号：13745-5 mg | 规格：5 mg | 目录价：￥8468.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
(R)-Butaprost
别名:
(±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester|15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester|TR 4978
产品描述:
Butaprost is a structural analog of PGE2 with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Serious confusion as to the structure of Butaprost was generated by Gardiner in 1986, when he reported that the epimer of butaprost showing this selective activity was the C-16 (R)-epimer (See Note). Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, FP, IP, or TP receptors.{6640} The pharmacology of (R)-butaprost has not been carefully studied, but it is generally considered to be the less active epimer. (NOTE: In the Gardiner paper in the 1986 British Journal of Pharmacology, butaprost appears on page 46 where it is given the name TR 4979. The structure as drawn is incorrect, in that the author was using and referring to the more active C-16 epimer, which is actually 16(S). The structure on page 46 shows the structure as 16(R). It was not until the late 1990’s that careful studies both in the US and Japan correctly identified the actual configuration of C-16 in the compound called butaprost is 16(S).)
保存温度:
-20
运输温度:
-20
预期分子量:
408.6
产品形式:
A 5 mg/ml solution in methyl acetate
有效期:
1460
纯度:
≥98%
CAS号:
69648-38-0
分子式:
C24H40O5
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