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折扣/货期| 货号：12087-100 mg | 规格：100 mg | 目录价：￥2184.2 |
| 货号：12087-250 mg | 规格：250 mg | 目录价：￥4489 |
| 货号：12087-50 mg | 规格：50 mg | 目录价：￥1286.4 |
| 货号：12087-500 mg | 规格：500 mg | 目录价：￥6405.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
(R)-Crizotinib
别名:
PF 2341066
产品描述:
A dual inhibitor of c-Met and ALK (IC50s = 8 and 20 nM, respectively, in a cell-based assay); selective for c-Met and ALK over several other receptor and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741, and >10 µM, respectively); selectively inhibits the proliferation of cancer cell lines with MET amplifications over cancer cell lines with MET or EGFR mutations (IC50s = 5-10, 472-1,284, and 767-787 nM, respectively); induces apoptosis in MET-amplified EBC-1 and NCI H1993 cells at 100 nM; reduces tumor volume in an EBC-1 mouse xenograft model at 25 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
450.3
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
877399-52-5
分子式:
C21H22Cl2FN5O
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