RAB13 Antibody-单抗-深圳欣博盛生物科技有限公司

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RAB13 Antibody

品牌：NSJ Bio

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说明书

折扣/货期

货号：F53816-0.05ML	规格：0.05 ml	目录价：￥2962
货号：F53816-0.2ML	规格：0.2 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

RAB13 Antibody

产品描述:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

反应种属:

Human

宿主来源:

Mouse

实验应用:

同种型:

Mouse IgG1

免疫原:

A human recombinant protein corresponding to amino acids 1-203 was used as the immunogen for the RAB13 antibody.

克隆性:

Monoclonal (mouse origin)

克隆号: