| 货号:RQ4897 | 规格:100 ug | 目录价:¥6488.05 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
RAB5A Antibody
产品描述:
RAB5A (Ras-associated protein RAB5A), also called RAB5, is a protein that in humans is encoded by the RAB5A gene. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. The RAB5A gene is mapped on 3p24.3. RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling. It signals to the actin cytoskeleton through RNTRE, a RAB5-specific GTPase-activating protein (GAP).RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes. In addition, RAB5 activation is either continuous or repetitive for up to 10 minutes, but it ends before the collapse of engulfed apoptotic cells. Expression of a dominant-negative mutant of RAB5 delayed this collapse of apoptotic thymocytes, showing a role for RAB5 in phagosome maturation.
反应种属:
Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
WB, FACS, IF
同种型:
Mouse IgG2b
免疫原:
Amino acids KKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN from the human protein were used as the immunogen for the RAB5A antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
3E9.
纯化方式:
Purified
保存温度:
After reconstitution, the RAB5A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
产品形式:
Purified
存储溶液:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
产地:
美国
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