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折扣/货期| 货号：23820-1 mg | 规格：1 mg | 目录价：￥657 |
| 货号：23820-10 mg | 规格：10 mg | 目录价：￥4744 |
| 货号：23820-5 mg | 规格：5 mg | 目录价：￥2546 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RAF709
产品描述:
A potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively); selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases; DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM; inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM); reduces ERK phosphorylation and decreases tumor volume without affecting total body weight in a Calu-6 mouse NSCLC xenograft model when administered at doses ranging from 10-200 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
542.6
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1628838-42-5
分子式:
C28H29F3N4O4
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