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折扣/货期| 货号：F54143-0.08ML | 规格：0.08 ml | 目录价：￥2962.25 |
| 货号：F54143-0.4ML | 规格：0.4 ml | 目录价：￥6343.55 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RBCK1 Antibody
产品描述:
RanBP-type and C3HC4-type zinc finger-containing protein 1 is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. [UniProt]
反应种属:
Human, Mouse
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
免疫原:
A portion of amino acids 16-46 from the human protein was used as the immunogen for the RBCK1 antibody.
克隆性:
Polyclonal (rabbit origin)
保存温度:
Aliquot the RBCK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
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