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折扣/货期| 货号：100-03-100UG | 规格：100 ug | 目录价：￥5974 |
| 货号：100-03-10UG | 规格：10 ug | 目录价：￥1207 |
| 货号：100-03-1MG | 规格：1 mg | 目录价：￥26524 |
| 货号：100-03-250UG | 规格：250 ug | 目录价：￥11576 |
| 货号：100-03-500UG | 规格：500 ug | 目录价：￥17199 |
| 货号：100-03-50UG | 规格：50 ug | 目录价：￥3008 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant Human Heregulinbeta-1
别名:
Neuregulin1 (NRG1-beta1), Neu differentiation factor (rat), HRG, HRG1-beta1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor
产品描述:
Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-beta1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinbeta-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinbeta-1 (65 amino acid residues).
宿主来源:
E.coli
保存温度:
Minus 20C
运输温度:
Room Temperature
产品形式:
Bulk
产地:
美国
生产商:
PeproTech
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