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折扣/货期| 货号：42185-1 mg | 规格：1 mg | 目录价：￥817 |
| 货号：42185-10 mg | 规格：10 mg | 目录价：￥6486 |
| 货号：42185-25 mg | 规格：25 mg | 目录价：￥11149 |
| 货号：42185-5 mg | 规格：5 mg | 目录价：￥3658 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RMC-7977
产品描述:
A wild-type and mutant Ras protein-protein interaction inhibitor; inhibits the interaction between wild-type K-Ras and seven activating mutation-containing K-Ras variants and C-RAF (EC50s = 5.06-34.5 nM) and the same K-Ras variants and cyclophilin A (EC50s = 1.27-9.12 nM) in BRET assays using U2OS cells expressing the human proteins; inhibits the protein-protein interactions between wild-type N-Ras, N-RasQ61K, N-RasQ61L, and N-RasQ61R and B-RAF (EC50s = 57.7, 53.9, 145, and 181 nM, respectively, in TR-FRET assays) and wild-type H-Ras and H-RasG13R and B-RAF (EC50s = 59.9 and 23.7 nM, respectively, in TR-FRET assays); has antiproliferative activity against a panel of 183 K-Ras-dependent cancer cell lines (median EC50 = 2.4 nM); reduces the proliferation of adagrasib-resistant NCI H358 cells at 10 nM; reduces tumor volumes in SW620 colon, HPAC pancreatic, and NCI H441 lung cancer mouse xenograft models at 10 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
865.09562
产品形式:
A solid
纯度:
≥95%
CAS号:
2765082-12-8
分子式:
C47H60N8O6S
促销活动
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