RuvB-like 1 Antibody / RUVBL1 / TIP49A-多抗-深圳欣博盛生物科技有限公司

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RuvB-like 1 Antibody / RUVBL1 / TIP49A

品牌：NSJ Bio

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说明书

折扣/货期

货号：F54729-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F54729-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

RuvB-like 1 Antibody / RUVBL1 / TIP49A

产品描述:

RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 -CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

WB, FACS, IHC-P

同种型:

Rabbit Ig

免疫原:

Recombinant human protein was used as the immunogen for the RuvB-like 1 antibody.

克隆性:

Polyclonal (rabbit origin)