官网链接
折扣/货期| 货号：38777-10 mg | 规格：10 mg | 目录价：￥2117 |
| 货号：38777-25 mg | 规格：25 mg | 目录价：￥4985 |
| 货号：38777-5 mg | 规格：5 mg | 目录价：￥1112 |
| 货号：38777-50 mg | 规格：50 mg | 目录价：￥8844 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RVX-297
产品描述:
A BD2 bromodomain inhibitor; inhibits BD2 in BRD2, BRD3, and BRD4 (IC50s = 0.08, 0.05, and 0.02 µM, respectively) and is selective for BD2 over BD1 (IC50s = 3.76, 2.34, and 1.16 µM for BRD2, BRD3, and BRD4, respectively), as well as CREBBP and p300 (IC50s = >50 µM for both); decreases levels of the mRNAs encoding IL-6 and VCAM-1 in primary synovial fibroblasts isolated from patients with rheumatoid arthritis at 10 and 30 µM; It prevents LPS-induced increases in IL-6 and Ifn-γ serum levels in a mouse model of LPS-induced endotoxemia at 75 mg/kg; inhibits collagen-induced increases in ankle and knee diameter, cartilage damage, the ankle tissue levels of mRNAs encoding IL-1β, Mmp-3, Mmp-13, and Rankl, and ankle joint protein levels of IL-6 and VCAM-1 in a rat model of collagen-induced rheumatoid arthritis at 25, 50, and 75 mg/kg twice per day; improves gait and mobility and reverses body weight loss, as well as decreases the number of spinal cord inflammatory foci and apoptotic cells and reduces spinal nerve demyelination in a mouse model of EAE at 75 and 125 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
423.50488
产品形式:
A solid
纯度:
≥95%
CAS号:
1044871-04-6
分子式:
C24H29N3O4
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