Sabizabulin-其他小分子化合物-深圳欣博盛生物科技有限公司

首页产品中心其他小分子化合物

Sabizabulin

品牌：Cayman

官网链接

说明书

折扣/货期

货号：38525-1 mg	规格：1 mg	目录价：￥1997
货号：38525-5 mg	规格：5 mg	目录价：￥6472

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Sabizabulin

别名:

ABI-231|VERU-111

产品描述:

An inhibitor of tubulin polymerization; inhibits bovine tubulin polymerization in a cell-free assay at 5 and 10 µM; inhibits the growth of A375, WM164, LNCaP, PC3, and DU145 cells, as well as paclitaxel-resistant PC3 cells (IC50s = 3.2, 5.3, 2.8, 3.7, 3.9, and 3.7 nM, respectively); reduces the migration and invasion of MDA-MB-231 and MDA-MB-468 cells at 8 nM, as well as decreases the migration rate in wound-healing assays using the same cells at 16 nM; induces cell cycle arrest at the G2/M phase in MDA-MB-231 cells and the G2 phase in MDA-MB-468 cells, as well as apoptosis in these same cells, at 50 nM; decreases tumor volume, tumor weight, and angiogenesis, as well as increases tumor necrosis, without affecting body weight, in an MDA-MB-231 mouse xenograft model at 5, 10, 12.5 mg/kg; reduces the number of lung, liver, and kidney metastases in an MDA-MB-231 mouse xenograft model of metastasis at 10 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

377.39338

产品形式:

A solid

纯度:

≥98%

CAS号:

1332881-26-1