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折扣/货期| 货号：21717-1 mg | 规格：1 mg | 目录价：￥549 |
| 货号：21717-10 mg | 规格：10 mg | 目录价：￥4181 |
| 货号：21717-25 mg | 规格：25 mg | 目录价：￥9112 |
| 货号：21717-5 mg | 规格：5 mg | 目录价：￥2385 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SAR407899
产品描述:
An ATP-competitive inhibitor of ROCK1 and ROCK2 (IC50s = 102 and 276 nM, respectively at a concentration of 40 μM ATP); selective for ROCK over 79 other kinases at IC50 values up to 10 μM but had IC50 values ranging from 1 to 10 μM for RSK, PKB, PKCδ, and MSK-1; selective for ROCK over 115 receptor and enzyme targets at IC50 values up to 10 μM, but it does inhibit the serotonin transporter and µ-opioid receptors with IC50s values of 1.1 and 8.9 μM, respectively; inhibits ROCK-mediated phosphorylation of MYPT, thrombin-induced stress fiber formation, PDGF-induced proliferation, and MCP-1-stimulated chemotaxis; relaxes precontracted isolated arteries from various species (IC50s = 122-280 nM) and precontracted corpora cavernosa in both healthy and diabetic animals (IC50s = 0.05-0.42 μM); inhibits ET-1-induced constriction of rat and human arteries (Emaxs = 24-83% of control)
保存温度:
-20
运输温度:
-20
预期分子量:
244.3
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
923359-38-0
分子式:
C14H16N2O2
促销活动
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