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折扣/货期| 货号：70340-1 mg | 规格：1 mg | 目录价：￥281 |
| 货号：70340-10 mg | 规格：10 mg | 目录价：￥2037 |
| 货号：70340-25 mg | 规格：25 mg | 目录价：￥4409 |
| 货号：70340-5 mg | 规格：5 mg | 目录价：￥1152 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SC-560
产品描述:
SC-560 is a member of the diaryl heterocycle class of COX inhibitors which includes celecoxib (Celebrex™) and rofecoxib (Vioxx™). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 µM.{7675} Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of TXB2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.{1282} In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor.{14472} The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.
保存温度:
-20
运输温度:
-20
预期分子量:
352.7
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
188817-13-2
分子式:
C17H12ClF3N2O
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