SDF-1alpha [CXCL12] (human):Fc (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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SDF-1alpha [CXCL12] (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HF-210SDF1A-C050

规格：50 ug

目录价：￥4340

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SDF-1alpha [CXCL12] (human):Fc (human) (rec.)

别名:

CXCL12; C-X-C Motif Chemokine 12; PBSF; SCYB12; TLSF; TPAR1

产品描述:

The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine that belongs to the CXC chemokine subfamily. SDF1 is widely expressed in various organs including heart, liver, brain, kidney, skeletal muscle, and lymphoid organs, and is highly conserved between species. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1alpha and SDF1beta, which are identical except for the four residues present in the C-terminus of SDF1beta but absent from SDF1alpha. As a highly efficacious lymphocyte chemoattractant, SDF1 activates and directs the migration of leukocytes in response to proinflammatory stimuli such as LPS, TNF, or interleukins. It has been demonstrated that SDF1 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and thus plays an important role in carcinoma pathogenesis. In addition, SDF1 is identified as the biological ligand for CXC-chemokine receptor 4 (CXCR4), which is widely expressed in leukocytes and acts as the cofactor for HIV-1 entry, and inhibits the HIV-1 infection. Furthermore, SDF1 is rapidly inactivated via N-terminal processing by cathepsin G associated with the membrane of B-cells, NK cells and to a lesser extent, T-cells.

宿主来源:

HEK 293 cells

保存温度:

+4°C

运输温度:

预期分子量:

~35kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

产地: