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折扣/货期| 货号：35442-10 mg | 规格：10 mg | 目录价：￥1139 |
| 货号：35442-25 mg | 规格：25 mg | 目录价：￥2211 |
| 货号：35442-5 mg | 规格：5 mg | 目录价：￥643 |
| 货号：35442-50 mg | 规格：50 mg | 目录价：￥4100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SIB 1757
产品描述:
An antagonist of mGluR5a; selectively inhibits glutamate-induced calcium release and quisqualate-induced phosphoinositol accumulation in fibroblasts expressing human mGluR5a (IC50s = 0.37 and 3.1 µM, respectively) over mGluR1b-expressing fibroblasts (IC50s = >100 µM for both); selective for mGluR5a over mGluR2, mGluR3, mGluR4a, mGluR6, mGluR7b, mGluR8 (IC50s = >100 µM for all) as well as AMPA, kainate, and NMDA receptors (IC50s = >30 µM for all); inhibits (S)-3,5-DHPG-induced phosphoinositol accumulation in isolated neonatal rat hippocampus and striatum (IC50s = 5.2 and 10.1 µM, respectively); intrathecal administration increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain at 0.01 µg/animal
保存温度:
-20
运输温度:
-20
预期分子量:
213.23536
产品形式:
A solid
纯度:
≥95%
CAS号:
31993-01-8
分子式:
C12H11N3O
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