官网链接
折扣/货期| 货号：10007974-10 mg | 规格：10 mg | 目录价：￥1943 |
| 货号：10007974-100 mg | 规格：100 mg | 目录价：￥13226 |
| 货号：10007974-5 mg | 规格：5 mg | 目录价：￥1018 |
| 货号：10007974-50 mg | 规格：50 mg | 目录价：￥8147 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SLF
别名:
Synthetic Ligand of FKBP
产品描述:
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation.{13842} SLF is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin.{13706} By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment.{13701,13706} For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.{13701}
保存温度:
-20
运输温度:
-20
预期分子量:
524.7
产品形式:
A 50 mg/ml solution in ethanol
纯度:
≥98%
CAS号:
195513-96-3
分子式:
C30H40N2O6
您可能感兴趣的产品
2-Oxoarginine
货号：9004337-1 mg
LCC-12 (formate)
货号：46743-1 mg
Guanosine 5′-diphospho-D-mannose (sodium salt)
货号：46575-10 mg
Necrocide 1
货号：46570-1 mg
2'-O-Methylpseudouridine
货号：46554-1 mg
Nampt Activator-1
货号：46510-10 mg
1-(3-Hydroxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione
货号：46507-100 mg
DS-6930
货号：46506-1 mg
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询