SMAD3 Antibody-多抗-深圳欣博盛生物科技有限公司

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SMAD3 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F53157-0.08ML	规格：0.08 ml	目录价：￥2962
货号：F53157-0.4ML	规格：0.4 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SMAD3 Antibody

产品描述:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]

反应种属:

Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, ELISA

同种型:

Rabbit Ig

免疫原:

This SMAD3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 186-219 amino acids from the Central region of human SMAD3.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

Aliquot the SMAD3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

产品形式:

Antigen affinity purified

存储溶液:

In 1X PBS, pH 7.4, with 0.09% sodium azide

产地:

美国