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折扣/货期| 货号：34890-1 mg | 规格：1 mg | 目录价：￥724 |
| 货号：34890-10 mg | 规格：10 mg | 目录价：￥4569 |
| 货号：34890-25 mg | 规格：25 mg | 目录价：￥9608 |
| 货号：34890-5 mg | 规格：5 mg | 目录价：￥2640 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SN-011
别名:
GUN35901
产品描述:
A STING antagonist; binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in MEFs, BMDMs, and HFFs (IC50s = 127.5, 107.1, and 502.8 nM, respectively); impairs recruitment of IRF3 or TBK1 to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits HSV-1-induced translocation of STING from the ER to the Golgi at 1 µM; increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome at 5 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
462.493843
产品形式:
A solid
纯度:
≥98%
CAS号:
2249435-90-1
分子式:
C25H19FN2O4S
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