SS18-SSX Antibody / Protein SSXT-单抗-深圳欣博盛生物科技有限公司

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SS18-SSX Antibody / Protein SSXT

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5838-100UG	规格：100 ug	目录价：￥6652
货号：V5838-20UG	规格：20 ug	目录价：￥3082

产品详情

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产品名称:

SS18-SSX Antibody / Protein SSXT

产品描述:

S18 is a protein that has been shown to be a part of the SWI/SNF complex. The SS18-SSX fusion proteins are a result of in-frame fusions that fuse the SS18 gene on chromosome 18 with X chromosome genes SSX1, SSX2, and to a lesser extent SSX4. Human synovial sarcoma (SS) accounts for 8-10% of all soft tissue malignancies and 95% of these malignancies express the recurrent translocation of the SS18 gene on chromosome 18. The N-terminal SNH domain (SYT N-terminal homology domain) of the SS18 protein interacts with SWI/SNF chromatin remodeling complexes via the N terminal region of BRM and BRG1 subunits. Studies of the SS18-SSX fusion in SS suggest that endogenous SS18 competes with the mutant SS18-SSX fusion for occupancy in the SWI/SNF complexes resulting in the displacement of SNF5 (BAF47) subunit. Displacement of the SNF5 subunit results in altered function of the SWI/SNF complex that leads to deregulated expression of genes such as Sox2 in synovial sarcoma.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P, WB

同种型:

Rabbit IgG, kappa

免疫原:

A recombinant fragment corresponding to the fusion site of human SS18-SSX protein was used as the immunogen for the SS18-SSX antibody.

克隆性:

Recombinant Rabbit Monoclonal