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折扣/货期| 货号：V5838-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V5838-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SS18-SSX Antibody / Protein SSXT
产品描述:
S18 is a protein that has been shown to be a part of the SWI/SNF complex. The SS18-SSX fusion proteins are a result of in-frame fusions that fuse the SS18 gene on chromosome 18 with X chromosome genes SSX1, SSX2, and to a lesser extent SSX4. Human synovial sarcoma (SS) accounts for 8-10% of all soft tissue malignancies and 95% of these malignancies express the recurrent translocation of the SS18 gene on chromosome 18. The N-terminal SNH domain (SYT N-terminal homology domain) of the SS18 protein interacts with SWI/SNF chromatin remodeling complexes via the N terminal region of BRM and BRG1 subunits. Studies of the SS18-SSX fusion in SS suggest that endogenous SS18 competes with the mutant SS18-SSX fusion for occupancy in the SWI/SNF complexes resulting in the displacement of SNF5 (BAF47) subunit. Displacement of the SNF5 subunit results in altered function of the SWI/SNF complex that leads to deregulated expression of genes such as Sox2 in synovial sarcoma.
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IHC-P, WB
同种型:
Rabbit IgG, kappa
免疫原:
A recombinant fragment corresponding to the fusion site of human SS18-SSX protein was used as the immunogen for the SS18-SSX antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
SS18.SSX/12628R
纯化方式:
Protein A affinity
保存温度:
Aliquot the SS18-SSX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
产地:
美国
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