STK15 Antibody / Serine/threonine-protein kinase 15 / AURKA-多抗-深圳欣博盛生物科技有限公司

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STK15 Antibody / Serine/threonine-protein kinase 15 / AURKA

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ7272

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

STK15 Antibody / Serine/threonine-protein kinase 15 / AURKA

产品描述:

AURKA (Aurora kinase A), also called ARK1, AurA, AIK , AURORA2, BTAK, PPP1R47, STK7, STK15, STK6, is a mitotic centrosomal protein kinase. The main role of STK15 in tumor development is in controlling chromosome segregation during mitosis. It is a member of a family of mitotic serine/threonine kinases. Cell cycle and Northern blot analyses showed that peak expression of STK15 occurs during the G2/M phase and then decreases. By fluorescence in situ hybridization, AURKA gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression of Aurora kinase A / Serine/threonine-protein kinase 15 in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Depletion of Ajuba prevented activation of STK15 at centrosomes in late G2 phase and inhibited mitotic entry. Activation of STK15 was independently sufficient to induce rapid ciliary resorption, and STK15 acted in this process through phosphorylation of HDAC6, leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme. Small molecule inhibitors of STK15 and HDAC6 reduced regulated disassembly of cilia.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

WB, IHC-P, FACS, Direct ELISA

同种型:

Rabbit IgG

免疫原:

Recombinant human protein (amino acids K23-S403) was used as the immunogen for the STK15 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity purified

保存温度:

After reconstitution, the STK15 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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