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折扣/货期| 货号：F54140-0.05ML | 规格：0.05 ml | 目录价：￥2962.25 |
| 货号：F54140-0.2ML | 规格：0.2 ml | 目录价：￥6343.55 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
STUB1 Antibody (C-Terminal Region)
产品描述:
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. [UniProt]
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
WB
同种型:
Mouse IgG1, kappa
免疫原:
Recombinant human STUB1 was used as the immunogen for the STUB1 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
1008CT12.4.1
纯化方式:
Protein G purified
保存温度:
Aliquot the STUB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
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