深圳欣博盛生物科技有限公司

SURF6 Antibody / Surfeit locus protein 6

SURF6 antibody detects Surfeit locus protein 6, a nucleolar protein involved in ribosome biogenesis and pre-rRNA processing. The UniProt recommended name is Surfeit locus protein 6 (SURF6). This evolutionarily conserved nucleolar factor functions as a scaffold for ribonucleoprotein complex assembly during early steps of ribosome formation.

Functionally, SURF6 antibody identifies a 360-amino-acid protein localized to the granular component of the nucleolus, where it associates with pre-rRNA transcripts and ribosomal assembly intermediates. SURF6 interacts with fibrillarin and nucleolin, facilitating pre-rRNA maturation and 60S ribosomal subunit formation. Its RNA-binding capacity and nucleolar localization signal make it an essential factor for ribosome production and nucleolar organization.

The SURF6 gene is located on chromosome 9q34.2 and is expressed ubiquitously, with high levels in proliferating and metabolically active cells. Expression correlates with cellular growth rate, reflecting its role in ribosome synthesis and protein translation capacity.

Pathologically, dysregulation of SURF6 expression has been linked to oncogenesis and stress response modulation. Overexpression is observed in various cancers and is associated with increased ribosome biogenesis and cell proliferation. Conversely, depletion of SURF6 triggers nucleolar stress, p53 activation, and growth arrest. Research using SURF6 antibody supports studies in ribosome assembly, nucleolar dynamics, and cancer biology.

SURF6 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect nucleolar proteins. NSJ Bioreagents provides SURF6 antibody reagents optimized for studies in ribosomal biogenesis, nucleolar organization, and cellular stress response.

Structurally, Surfeit locus protein 6 contains arginine-rich motifs that mediate RNA binding and multiple acidic stretches that promote protein-protein interactions within the nucleolus. Its modular domains contribute to the architecture of the ribosomal assembly machinery. This antibody facilitates exploration of SURF6's function in nucleolar integrity and ribosome maturation.

Human

Rabbit

WB, ICC, IF, ELISA

Rabbit IgG

E.coli-derived human SURF6 recombinant protein (Position: M1-R216) was used as the immunogen for the SURF6 antibody.

Polyclonal (rabbit origin)

Immunogen affinity purified

After reconstitution, the SURF6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml

美国