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折扣/货期| 货号：28448 | 规格：1 mg | 目录价：￥2265 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TAK-220
产品描述:
An orally bioavailable CCR5 antagonist; binds to human CCR5 (IC50 = 3.5 nM), but not to CCR1, CCR2b, CCR3, CCR4, or CCR7, expressed in CHO cells; inhibits the binding of CCL5 and CCL3 to CCR5 (IC50s = 3.5 and 1.4 nM, respectively) but not the binding of CCL4; inhibits HIV-1 envelope-mediated membrane fusion in an M-tropic R5 but not in a T-tropic X4 HIV-1 strain (IC50s = 0.42 and >1,000 nM, respectively); inhibits the replication of six strains of R5 HIV-1 clinical isolates (EC90 overall mean = 13 nM) and the R5 JR-FL laboratory-adapted strain (EC50 = 0.6 nM), but not of X4 HIV-1 clinical isolates or the X4 IIIB laboratory-adapted strain (EC50s = >10,000 nM for both), in human PBMCs
保存温度:
-20
运输温度:
-20
预期分子量:
553.1351
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
333994-00-6
分子式:
C31H41ClN4O3
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