官网链接
折扣/货期| 货号：35754-1 mg | 规格：1 mg | 目录价：￥2117 |
| 货号：35754-5 mg | 规格：5 mg | 目录价：￥6325 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Takeda-6d
产品描述:
A dual inhibitor of RAF kinases and VEGFR2; inhibits wild-type B-RAF, mutant B-RAFV600E, and C-RAF (IC50s = 12, 7, and 1.5 nM, respectively), as well as VEGFR2 (IC50 = 2.8 nM); selective for these kinases over a panel of 19 additional kinases (IC50s = >1,000 nM) but does inhibit FGFR3, PDGFRα, and PDGFRβ (IC50s = 22, 12, and 5.5 nM, respectively); inhibits MEK and ERK1/2 phosphorylation in several colon cancer and melanoma cell lines expressing B-RAFV600E from 100-1,600 nM; inhibits VEGF-A-induced phosphorylation of VEGFR2 in VEGFR2-overexpressing KDR cells (IC50 = 0.53 nM); reduces tumor volume in an A375 melanoma mouse xenograft model at 10 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
547.988763
产品形式:
A solid
纯度:
≥95%
CAS号:
1125632-93-0
分子式:
C27H19ClFN5O3S
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询