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折扣/货期| 货号：16289-1 mg | 规格：1 mg | 目录价：￥844 |
| 货号：16289-10 mg | 规格：10 mg | 目录价：￥2760 |
| 货号：16289-25 mg | 规格：25 mg | 目录价：￥6271 |
| 货号：16289-5 mg | 规格：5 mg | 目录价：￥1729 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TG101348
别名:
Fedratinib|SAR302503
产品描述:
A JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes); is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and TYK2, respectively; selective for JAK2 over a panel of 34 kinases at 500 nM; inhibits FLT3 and RET (IC50s = 15 and 48 nM, respectively); reduces the proliferation of HEL cells as well as Ba/F3 murine cells expressing JAK2V617F (IC50s = 305 and 270 nM, respectively); inhibits the differentiation of hematopoietic stem cells and myeloid progenitor cells isolated from patients with polycythemia vera at 300 nM; improves survival and reduces spleen weight in a syngeneic mouse model of polycythemia vera induced by transplantation of Jak2V617F-expressing whole bone marrow at 60 and 120 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
524.7
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
936091-26-8
分子式:
C27H36N6O3S
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