TMI 1-抑制剂-深圳欣博盛生物科技有限公司

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TMI 1

品牌：Cayman

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说明书

折扣/货期

货号：29713-10 mg	规格：10 mg	目录价：￥4060
货号：29713-5 mg	规格：5 mg	目录价：￥2265

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TMI 1

产品描述:

An ADAM and MMP inhibitor; inhibits ADAM17/TACE (IC50 = 8.4 nM in a cell-free enzyme assay); inhibits MMP-1, -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC50s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively); inhibits ADAM8, -10, -12, and -17/TACE (Kis = 21, 16, 1.8, and 0.079 nM, respectively, in cell-free enzyme assays); inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC50s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC50s = 190 and 300 nM, respectively); inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis (IC50s = 50 = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis; decreases cell viability of (ED50s = 1.3-8.1 µM) and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer at 100 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

398.49906

产品形式:

A solid

纯度:

≥98%

CAS号:

287403-39-8