TNF-alpha (mouse) (multimeric) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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TNF-alpha (mouse) (multimeric) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0021-3010	规格：3 x 10 ug	目录价：￥4560
货号：AG-40B-0021-C010	规格：10 ug	目录价：￥2280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TNF-alpha (mouse) (multimeric) (rec.)

别名:

MultimericTNF-alpha™; ACRP30headless:TNF-alpha; ACRP30headless:TNFSF2; ACRP30headless:Tumor Necrosis Factor-alpha

产品描述:

Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha™ can be used.

宿主来源:

HEK 293 cells

靶标/特异性:

Binds to human and mouse TNF-R1 and TNF-R2.

产品浓度:

0.1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~34kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized. Contains PBS.

产地:

瑞士

纯度:

>95% (SDS-PAGE)

生物活性:

Activates human and mouse TNF-R1 and TNF-R2. Induces cell death at a concentration range of 0.01-10ng/ml (ED50= 0.05ng/ml or 2 x 10E7 Units/mg; WEHI 164 cells).

内毒素水平:

<0.02EU/µg purified protein (LAL test; Lonza).

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