TP-0903-抑制剂-深圳欣博盛生物科技有限公司

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TP-0903

品牌：Cayman

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说明书

折扣/货期

货号：28757-1 mg	规格：1 mg	目录价：￥496
货号：28757-10 mg	规格：10 mg	目录价：￥3980
货号：28757-25 mg	规格：25 mg	目录价：￥8750
货号：28757-5 mg	规格：5 mg	目录价：￥2251

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TP-0903

产品描述:

An inhibitor of Axl (IC50 = 27 nM ); exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively; decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively); decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells at 30 nM; reduces the viability of CRC cell lines (IC50s = 4.5-123 nM); exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC PDX mouse model, respectively, at 40 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

516.05968

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

1341200-45-0