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折扣/货期| 货号：23397-1 mg | 规格：1 mg | 目录价：￥482 |
| 货号：23397-10 mg | 规格：10 mg | 目录价：￥3591 |
| 货号：23397-25 mg | 规格：25 mg | 目录价：￥7866 |
| 货号：23397-5 mg | 规格：5 mg | 目录价：￥2050 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TPX-0005
别名:
Repotrectinib
产品描述:
A multi-kinase inhibitor; inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as ROS1 (IC50 = 0.07 nM); inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively); inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with certain compounds, including osimertinib; reduces tumor growth in PC-9 and H1975 mouse xenograft models; potentiates the effect of osimertinib on tumor growth in vivo
保存温度:
-20
运输温度:
-20
预期分子量:
355.4
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1802220-02-5
分子式:
C18H18FN5O2
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