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折扣/货期| 货号：AG-44B-0004-KI01 | 规格：1 Set | 目录价：￥13800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TRAIL-R1 to -R4 (human) Flow Cytometry Pack
产品描述:
TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
保存温度:
+4°C
运输温度:
BI
产地:
瑞士
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