TRAIL, Soluble (human) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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TRAIL, Soluble (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0003-5010	规格：5 x 10 ug	目录价：￥2520
货号：AG-40B-0003-C010	规格：10 ug	目录价：￥840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TRAIL, Soluble (human) (rec.)

别名:

Apo-2L; TNFSF10; CD253

产品描述:

TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to fi ve distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2;TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducingthe formation of the so-called multiprotein death-inducing signaling complex (DISC).

宿主来源:

E. coli

产品浓度:

0.1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~23kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized. Contains PBS.

产地:

瑞士

纯度:

>95% (SDS-PAGE)

生物活性:

Induces apoptosis of human Jurkat T cells in a concentration range of 5-50ng/ml in the presence of 1µg/ml TNF Ligands Enhancer (Prod. No. AG-35B-0001). In the absence of TNF Ligands Enhancer, TRAIL, Soluble (human) (recombinant) is poorly active.

内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).

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