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折扣/货期| 货号：23385-10 mg | 规格：10 mg | 目录价：￥1005 |
| 货号：23385-25 mg | 规格：25 mg | 目录价：￥2104 |
| 货号：23385-5 mg | 规格：5 mg | 目录价：￥549 |
| 货号：23385-50 mg | 规格：50 mg | 目录价：￥3672 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TRAM-34
产品描述:
A membrane-permeable blocker of IKCa1/KCa3.1 (Kds = 20 and 25 nM for the cloned and native channel in COS-7 cells and human T lymphocytes, respectively); 200- to 1,500-fold selective for IKCa1 over Kv (Kv1.1-Kv1.5, Kv3.1, Kv4.2), Kir2.1, BK/KCa1.1, SKCa (rSKCa2, hSKCa2, hSKCa3), native SKCa/KCa2, and CRAC in Jurkat T cells as well as sodium and chloride channels; suppresses reactivation of human-derived T lymphocytes stimulated with anti-CD3 antibody (mean EC50s = 295 and 910 nM from sensitive and less sensitive human donors, respectively); inhibits proliferation of human endometrial cancer cells and induces cell cycle arrest at the G0/G1 phase; inhibits proliferation of LNCaP and PC3 prostate cancer cells; inhibits proliferation induced by epidermal growth factor (EGF) in smooth muscle A7r5 cells (IC50 = 8 nM); reduces intimal hyperplasia by approximately 40% after 1, 2, and 6 weeks in a rat model of balloon catheter injury when administered at a dose of 120 mg/kg per day; pretreatment of HEC-1-A cells with TRAM-34 at a concentration of 30 μM inhibits tumor growth in vivo in nude mice
保存温度:
-20
运输温度:
-20
预期分子量:
344.8
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
289905-88-0
分子式:
C22H17ClN2
促销活动
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